Cancer Screening Kit
A test that analyzes BRCA 1 and BRCA 2 genes associated with potential risks for breast, ovaries, pancreas and prostate cancers.
Our BRCA testing kit consists of sequencing the full BRCA 1/2 genes using Next Generation Sequencing and analyzing all gene sequences using Bioinformatics tool to detect the genetic mutations.
Moreover, our target enrichment method allows to specifically isolate the BRCA 1,2 genomic loci out of the whole exome and thereby increases the sensitivity of detecting genetic mutations by producing higher coverage & depth sequencing data.
Around half of hereditary breast and ovarian cancers caused by the mutations in the BRCA1,2 genes.
The BRCA 1,2 genes function as a tumor suppressor, thereby they have an essential role in both DNA repair and cell cycle control systems.
And the studies have shown the BRCA1,2 gene mutation carriers have potential risk to develop specific cancers.
40%-80% for breast cancer
11%-40% for ovarian cancer
1%-10% for male breast cancer
Up to 39% for prostate cancer
1%-7% for pancreatic cancer
A comprehensive test that analyzes about 40 genes that are associated over Breast, Ovarian, Colorectal, Endometrial, Melanoma, Pancreatic, Gastric, Prostate and Lung cancers.
Our Cancer Screening consists of sequencing the full 40 oncogenes using Next Generation Sequencing and analyzing all gene sequences Bioinformatics tool to detect the genetic mutations.
Moreover, our target enrichment method allows to specifically isolate the 40 oncogenes genomic loci out of the whole exome and thereby increases the sensitivity of detecting genetic mutations by producing higher coverage & depth sequencing data.
Studies have shown the specific gene mutation carriers have potential risk to develop certain types of cancers.
CDHI mutations are known to be associated with hereditary diffuse gastric cancer. And mutation carriers have a 67% for men and 83% for women lifetime risk of developing cancer by age 80.
TP53 mutations are known to be associated with Li-Fraumeni syndrome. And the TP53 mutation carriers have a 21-49% lifetime risk of developing cancer by age 30 and a lifetime cancer risk of 68-93%.
- Analysis of Single Nucleotide Variation, Insertion/deletion
•Unparalleled flexibility in designing your own test by specifically isolating your genomic loci of interest.
Celemics' have come up with the most convenient kit for hospitals or labs with special needs. If you can't find kits in hand, if you provide us with the gene lists, we can help design a kit separately for users.
Celemics' will also make sure the kits are rebalanced for best results so you will not receive data that is unreadable.
Our Hereditary Cancer testing panel is designed to analyze 31 genes related to breast, ovarian, colorectal, endometrial, melanoma, pancreatic, gastric, prostate and lung cancers. Our panel specifically isolates CDS regions of 31 oncogenes, thereby increasing the detection sensitivity of genetic mutations.
TopQXSEP MagBead is an ideal matrix that can be used in various types of DNA purification.Nucleic acid, which is refined using TopQXSEP MagBead, can be applied in various experiments (e.g. manipulation, PCR, and DNA sequencing).
TopQXSEP MagBead binds DNA selectively, which protects DNA from potential inhibitors or contaminants by short incubation processes (i.e. selective integration with DNA). After purification washes, DNA receives selective protection and remains with beads.